By compa … Here, we present a 52,698-cell catalog of the TME transcriptome in human lung tumors at single-cell resolution, validated in independent samples where 40,250 additional cells were sequenced. Obesity is a major cancer risk factor, but how differences in systemic metabolism change the tumor microenvironment (TME) and impact anti-tumor immunity is not understood. Cancer cells are embedded in the tumor microenvironment (TME), a complex ecosystem of stromal cells. The activated fibroblasts in TME, known as cancer-associated fibroblasts (CAFs), construct the structure of microenvironment by synthesizing a large proportion of ECM in TME and have a significant impact on tumor progression and tumor therapy . Various cancers can disseminate to the bone, including the most common malignancies in men and women, prostate and breast cancer, respectively. Herein, … Here, we demonstrate that high-fat diet (HFD)-induced obesity impairs CD8 + T cell function in the murine TME, acceler … Tumor hypoxia is the situation where tumor cells have been deprived of oxygen.As a tumor grows, it rapidly outgrows its blood supply, leaving portions of the tumor with regions where the oxygen concentration is significantly lower than in healthy tissues.
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